Copper bis-Dipyridoquinoxaline Is a Potent DNA Intercalator that Induces Superoxide-Mediated Cleavage via the Minor Groove
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چکیده
منابع مشابه
Synthesis and DNA cleavage activity of a bifunctional intercalator-linked copper(II) macrocycle.
An intercalator-linked macrocycle 3,6-bis(dimethylamino)-10-(6-[1,4,7-triazacyclononane]hexyl) acridinium bromide was synthesized, its copper(ii) complex was prepared, and the DNA cleavage activity of this metal complex was compared to that of the intercalator-free (Cu[9]aneN(3))(2+) complex.
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The designed peptide pyridine-2-carboxamidonetropsin (2-PyN) binds to the minor groove of double-helical DNA at two very different sequences, 5’-TTTTT-3’ and 5’-TGTCA-3’, with comparable energetics but quite different structures. 2-PyN likely binds the 5’-TTTTT-3’ site as a 1:l complex, whereas 2-PyN binds 5’-TGTCA-3’ sites as a 2:l complex. In order to enhance the binding affinity of 2-PyN for...
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ژورنال
عنوان ژورنال: Molecules
سال: 2019
ISSN: 1420-3049
DOI: 10.3390/molecules24234301